Many modern cosmetic procedures promise to make skin look younger, but few can match the biological depth and ability to replenish polynucleotides. Polynucleotides work on the cells themselves, unlike other anti-ageing treatments that only cover up indications of ageing. They restore, rebuild, and renew the skin from the inside out, making it look healthier, firmer, and more radiant.
At Cavendish Clinic, where our practitioners specialise in advanced medical & aesthetic treatments, polynucleotide therapy has quickly become a favourite among clients who want natural, long-lasting rejuvenation. This polynucleotide treatment is grounded in science, supported by clinical studies and designed to enhance the skin’s own renewal processes.
Introduction
As we age, the architecture of our skin gradually weakens. Collagen levels drop, elastin fibres lose their strength, and it’s harder to keep the skin hydrated. These natural processes lead to familiar concerns: fine lines, dullness, uneven tone, sagging, and textural irregularities.
While modern aesthetic treatments offer impressive solutions, many people now seek options that look more natural, work more gradually and strengthen the skin rather than altering its structure. This is where polynucleotides have emerged as a breakthrough. They are not fillers, not neurotoxins and not skin boosters in the traditional sense. Instead, polynucleotides act as regenerative molecules that encourage the skin to behave like younger, healthier tissue again. They are essentially collagen-boosting injections.
This makes polynucleotide treatment one of the most advanced options for individuals wanting a refreshed, radiant appearance without dramatic changes or invasive procedures.
What Are Polynucleotides and How Do They Work?
Polynucleotides are DNA pieces that have been highly purified and are safe for use in living things. They usually come from salmon or trout because their DNA structure is very similar to that of humans. These long-chain molecules are meant to start the process of cell regeneration.
Here’s how they work scientifically:
- Cellular Activation
Polynucleotides attach to certain receptors in the skin, which makes fibroblasts (the cells that make collagen, elastin, and the extracellular matrix) work harder. Over time, this makes the skin stronger, more flexible, and better structured.
- Deep Hydration and Water Retention
One unique property of polynucleotides is their ability to attract and retain water in tissues. The skin cells will feel full and supple because their molecules can retain water.
- Anti-Inflammatory Action
Their anti-inflammatory and oxidative stress-reducing properties help skin feel more resilient and at ease. Those whose skin is particularly delicate, prone to rosacea, or aging due to inflammation can benefit greatly from this.
- Tissue Regeneration and Repair
Polynucleotides help the microcirculation work better and help new, healthier tissue grow back. They help fix cells that are broken, speed up healing, and get the skin back to its normal state.
The result is a skin that looks better and is healthier on the inside.
Benefits of Polynucleotide Anti-Ageing Therapy
Polynucleotide treatments offer a wide spectrum of benefits as they enhance multiple layers of skin function. Clients often notice improvements that go beyond what traditional injectables can achieve.
- Strengthened Skin Structure
By stimulating fibroblasts, polynucleotides rebuild the skin’s support network, improving firmness, thickness and density.
- Enhanced Collagen and Elastin Production
This leads to visibly smoother, more youthful-looking skin with improved bounce and elasticity.
- Long-lasting Hydration
When you drink enough water, your skin looks plump, dewy, and fresh. This is especially good for skin that is dull or dry.
- Smoother Texture and Reduced Lines
Fine lines soften gradually over weeks as the skin becomes stronger and more refined.
- Brighter, More Even Skin Tone
The regenerative properties help even out skin tone, fix sun damage, and make skin look less dull.
- Improved Healing and Reduced Inflammation
Ideal for those with delicate, reactive or compromised skin barriers.
How Polynucleotides Boost Collagen and Improve Skin Health
Collagen is important for keeping skin looking young, but our bodies stop making it as much after we turn 25. Many people stop making as much collagen by the time they turn 40. This causes their skin to sag, wrinkle, and lose its vitality. Polynucleotides help stop this decline by waking up the fibroblasts that make collagen and elastin.
- Direct Fibroblast Stimulation
Fibroblasts are “collagen factories” inside the skin. Polynucleotides activate them, encouraging them to produce fresh collagen and elastin.
- Improved Skin Microenvironment
They increase hydration and reduce oxidative damage, making the environment more favourable for collagen fibres to form and mature.
- Microcirculation Enhancement
Polynucleotides improve blood flow in the treated area, delivering essential nutrients and oxygen that support collagen synthesis.
- Strengthening of Extracellular Matrix
The extracellular matrix, which gives skin structure and firmness, becomes more organised and supported, making skin look healthier and tighter.
Polynucleotides not only help get rid of signs of ageing that are already there, but they also make the skin stronger from the inside so that it doesn’t get worse in the future.
What to Expect During the Procedure
A polynucleotide appointment at Cavendish Clinic begins with a thorough consultation, where one of our practitioners assesses your skin and discusses your desired outcome.
- Comprehensive Consultation
Your practitioner will assess your skin, understand your concerns and design a personalised Polynucleotides treatment plan.
- Skin Preparation
The treatment area is cleansed thoroughly. A topical anaesthetic may be applied to ensure maximum comfort.
- Injection Process
Using fine needles or a cannula, small amounts of polynucleotide gel are placed strategically into the skin. The technique varies based on the treatment area. For example, the under-eyes require a gentle, precise approach.
- Cooling or Soothing
Post-injection, your skin may be gently cooled or massaged to reduce redness.
- Quick Treatment Time
The entire process typically takes 20–30 minutes, making it a convenient, minimally invasive aesthetic procedure.
There is no need for preparation beforehand, and most clients return to their daily activities immediately after their collagen-boosting injections.
Polynucleotides vs Traditional Anti-Ageing Treatments
Fillers, anti-wrinkle injections, and skin boosters are all standard anti-ageing skin treatments that work. Polynucleotides, on the other hand, are a new type of treatment that works in a different way.
Fillers work by adding volume where structure has been lost, while anti-wrinkle injections soften expression lines by relaxing underlying muscles. Collagen boosting injections offer intensive hydration but don’t significantly strengthen the skin’s deeper architecture. Polynucleotides differ because they influence the cellular behaviour of the skin itself. They do not add volume, change movement or create a dramatic instant effect. Instead, they gradually rebuild skin quality from the inside.
Similarly, lasers and chemical peels are treatments that make the skin look younger by damaging it in a controlled way and then resurfacing it. Polynucleotides are much gentler on the skin because they work with it instead of against it. These are great for people who want to get better over time without the downtime or pain that comes with more invasive procedures.
Common Side Effects
Side effects are typically mild and temporary, such as:
- Redness
- Swelling
- Minor bruising
- Tenderness
These usually resolve within 24–48 hours.
Aftercare Guidelines
To ensure the best results:
- Avoid touching the treated area for 24 hours
- Skip intense exercise for a day
- Avoid saunas, steam rooms and extreme heat for 48 hours
- Keep your skincare routine gentle
- Stay hydrated and protect your skin with SPF
Your practitioner will provide personalised advice depending on your skin type and treatment area.
Polynucleotides are going to be the next big thing in skin care that helps it heal. They are based on medical research, change the skin, and are not too obvious. This treatment is a natural and very effective way to make fine lines less noticeable, add moisture, refresh the area around your eyes, or improve the overall health of your skin.
We make sure that your Polynucleotide treatment is done safely, accurately, and professionally at Cavendish Clinic by using a medical-led approach. Polynucleotides might be the next step in your pursuit of beauty if you want your skin to look younger and more radiant.
Frequently Asked Questions
- How do polynucleotides stimulate skin repair and rejuvenation?
They make fibroblasts work, keep the skin hydrated, improve microcirculation, and lower inflammation. All of these things help repair tissue and make new collagen.
- Are polynucleotide treatments safe for sensitive or ageing skin?
Yes. Their anti-inflammatory and biocompatible properties make them highly suitable for sensitive, irritated and mature skin types.
- How long do the results of polynucleotides last?
Results typically last 6–12 months, depending on lifestyle, age and skin condition. Maintenance treatments can prolong the benefits.
- What makes polynucleotides different from dermal fillers or skin boosters?
Fillers add volume, and skin boosters add hydration. Polynucleotides repair tissue, stimulate collagen, reduce inflammation and strengthen the skin matrix.
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